In this review, we examine examples of conservation of protein structural motifs in unrelated or non-homologous proteins. For this, we have selected three DNA-binding motifs: the histone fold, the helix-turn-helix motif, and the zinc finger, as well as the globin-like fold. We show that indeed similar structures exist in unrelated proteins, strengthening the concept that three-dimensional conservation might be more important than the primary amino acid sequence. © 2012 Sousounis et al.
CITATION STYLE
Sousounis, K., Haney, C. E., Cao, J., Sunchu, B., & Tsonis, P. A. (2012). Conservation of the three-dimensional structure in non-homologous or unrelated proteins. Human Genomics. Henry Stewart Publications. https://doi.org/10.1186/1479-7364-6-10
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