The growth factor TGF-ß1 is located inside a protein cage, and is thought to be released by force applied through integrin proteins. A structure of TGF-ß1 in complex with integrin αVß6 sheds light on the uncaging process. See Article p.55
CITATION STYLE
Ha, T. (2017). Growth factor rattled out of its cage. Nature, 542(7639), 40–41. https://doi.org/10.1038/nature21119
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