Predictive value of CD19 measurements for bacterial infections in children infected with human immunodeficiency virus

4Citations
Citations of this article
5Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

We investigated the predictive value of CD19 cell percentages (CD19%) for times to bacterial infections, using data from six pediatric AIDS Clinical Trials Group protocols and adjusting for other potentially prognostic variables, such as CD4%, CD8%, immunoglobulin (IgA) level, lymphocyte count, prior infections, prior zidovudine treatment, and age. In addition, we explored the combined effects of CD19% and IgG level in predicting time to infection. We found that a low CD19% is associated with a nonsignificant 1.2-fold increase in hazard of bacterial infection (95% confidence interval: 0.97, 1.49). In contrast, a high IgG level is associated with a nonsignificant 0.87-fold decrease in hazard of infection (95% confidence interval: 0.68, 1.12). CD4% was more prognostic of time to bacterial infection than CD19% or IgG level. Low CD19% and high IgG levels together lead to a significant (P < 0.01) 0.50-fold decrease in hazard (95% confidence interval: 0.35, 0.73) relative to low CD19% and low IgG levels. Similarly, in a model involving assay result changes (from baseline to 6 months) as well as baseline values, the effect of CD19% by itself is reversed from its effect in conjunction with IgG. In this model, CD19% that are increasing and high are associated with decreases in hazard of infection (P < 0.01), while increasing CD19% and increasing IgG levels are associated with significant (at the P = 0.01 level) fourfold increases in hazard of infection relative to stable CD19% and decreasing; stable, or increasing IgG levels. Our data suggest that CD19%, in conjunction with IgG level, provides a useful prognostic tool for bacterial infections. It is highly likely thai T-helper function impacts on B-cell function; thus, inclusion of CD4% in such analyses may greatly enhance the assessment of risk for bacterial infection.

References Powered by Scopus

Immunoglobulin V<inf>H</inf>3 gene products: Natural ligands for HIV gp120

284Citations
N/AReaders
Get full text

Intravenous Immune Globulin for the Prevention of Bacterial Infections in Children with Symptomatic Human Immunodeficiency Virus Infection

246Citations
N/AReaders
Get full text

Defective humoral immunity in pediatric acquired immune deficiency syndrome

192Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Prospective 5-year study of peripheral blood CD4<sup>+</sup>, CD8<sup>+</sup>, and CD19<sup>+</sup>/CD20<sup>+</sup> lymphocytes and serum Igs in children born to HIV-1<sup>+</sup> women

31Citations
N/AReaders
Get full text

Evaluation of immune survival factors in pediatric HIV-1 infection

15Citations
N/AReaders
Get full text

Combined antiretroviral therapy reduces hyperimmunoglobulinemia in HIV-1 infected children

12Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Betensky, R. A., Calvelli, T., & Pahwa, S. (1999). Predictive value of CD19 measurements for bacterial infections in children infected with human immunodeficiency virus. Clinical and Diagnostic Laboratory Immunology, 6(2), 247–253. https://doi.org/10.1128/cdli.6.2.247-253.1999

Readers' Seniority

Tooltip

Lecturer / Post doc 1

33%

PhD / Post grad / Masters / Doc 1

33%

Researcher 1

33%

Readers' Discipline

Tooltip

Medicine and Dentistry 1

100%

Article Metrics

Tooltip
Social Media
Shares, Likes & Comments: 13

Save time finding and organizing research with Mendeley

Sign up for free