New insights into the formation of azlactone heterocycles bearing different substituents are hereby presented. The sum of both kinetic and thermodynamic factors contributes for the formation of 2-alkyl or 2-aryl substituted azlactones, while the cyclization of 2-alcoxy azlactones is less favored. These results are in perfect accordance with experimental observations obtained by infrared (IR) and electrospray ionization mass spectrometry (ESI(+)-MS) of the crude reaction mixture.
CITATION STYLE
De Castro, P. P., Batista, G. M. F., Pinheiro, D. L. J., Dos Santos, H. F., & Amarante, G. W. (2018). Old drawback on azlactone formation revealed by a combination of theoretical and experimental studies. Journal of the Brazilian Chemical Society, 29(11), 2213–2219. https://doi.org/10.21577/0103-5053.20180155
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