Antidepressant-like effect of Ikwitang involves modulation of monoaminergic systems

2Citations
Citations of this article
15Readers
Mendeley users who have this article in their library.

Abstract

Depression is a chronic mental disorder. Inflammatory reactions have an important function in the pathophysiology of depression. Ikwitang (IW) has been used to treat fever and inflammatory diseases, however, its effect on depression has not been previously investigated. Therefore, the present study evaluated the possible antidepressant-like effect of IW using a forced swimming test (FST) in mice. IW was orally administered for 14 days. On the 14 day, IW was administered 1 h prior to the FST. The immobility durations of the IW groups (0.01, 0.1 and 1 g/kg) were significantly decreased, compared with those of the distilled water (D.W.) groups. The reduction of immobility duration by IW was associated with significant increases in the levels of serotonin, noradrenaline and estrogen receptor-β in the brain. IW significantly increased the levels of brain-derived neurotrophic factor and phosphorylated extracellular signal-regulated kinases, compared with the D.W. groups. In addition, the levels of inflammatory cytokines were significantly reduced following IW administration in the hippocampus and serum. In conclusion, the results of the present study suggested that the antidepressant effect of IW may be associated with the modulation of monoaminergic systems and inflammatory reactions.

Cite

CITATION STYLE

APA

Kim, H. Y., Jeong, H. J., & Kim, H. M. (2016). Antidepressant-like effect of Ikwitang involves modulation of monoaminergic systems. Molecular Medicine Reports, 13(3), 2815–2820. https://doi.org/10.3892/mmr.2016.4809

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free