The hypnotic close-response of propofol was compared with its combination with either bupivacaine-induced spinal block or intramuscular bupivacaine 12.5 mg in 105 men, divided into three groups of 35, undergoing lower abdominal, pelvic lower limb surgery. Dose-response curves were determined for each group using bootstrap analysis. Bupivacaine-induced spinal block at the level of T8-T9 was found to reduce the ED50 of propofol by 39%. While this enhancement of hypnotic effect by spinal block is mostly attributable to reduced afferent input, differences in its potency between drugs suggest a role for additional factors.
CITATION STYLE
Tverskoy, M., Fleyshman, G., Bachrak, L., & Ben-Shlomo, I. (1996). Effect of bupivacaine-induced spinal block on the hypnotic requirement of propofol. Anaesthesia, 51(7), 652–653. https://doi.org/10.1111/j.1365-2044.1996.tb07847.x
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