The art of hijacking: how Nsp1 impacts host gene expression during coronaviral infections

2Citations
Citations of this article
10Readers
Mendeley users who have this article in their library.

Abstract

Non-structural protein 1 (Nsp1) is one of the first proteins produced during coronaviral infections. It plays a pivotal role in hijacking and rendering the host gene expression under the service of the virus. With a focus on SARS-CoV-2, this review presents how Nsp1 selectively inhibits host protein synthesis and induces mRNA degradation of host but not viral mRNAs and blocks nuclear mRNA export. The clinical implications of this protein are highlighted by showcasing the pathogenic role of Nsp1 through the repression of interferon expression pathways and the features of viral variants with mutations in the Nsp1 coding sequence. The ability of SARS-CoV-2 Nsp1 to hinder host immune responses at an early step, the absence of homology to any human proteins, and the availability of structural information render this viral protein an ideal drug target with therapeutic potential.

Cite

CITATION STYLE

APA

Karousis, E. D. (2024, February 1). The art of hijacking: how Nsp1 impacts host gene expression during coronaviral infections. Biochemical Society Transactions. Portland Press Ltd. https://doi.org/10.1042/BST20231119

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free