Minocycline reduces reactive gliosis in the rat model of hydrocephalus

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Background: Reactive gliosis had been implicated in injury and recovery patterns associated with hydrocephalus. Our aim is to determine the efficacy of minocycline, an antibiotic known for its anti-inflammatory properties, to reduce reactive gliosis and inhibit the development of hydrocephalus.Results: The ventricular dilatation were evaluated by MRI at 1-week post drugs treated, while GFAP and Iba-1were detected by RT-PCR, Immunohistochemistry and Western blot. The expression of GFAP and Iba-1 was significantly higher in hydrocephalic group compared with saline control group (p < 0.05). Minocycline treatment of hydrocephalic animals reduced the expression of GFAP and Iba-1 significantly (p < 0.05). Likewise, the severity of ventricular dilatation is lower in minocycline treated hydrocephalic animals compared with the no minocycline group (p < 0.05).Conclusion: Minocycline treatment is effective in reducing the gliosis and delaying the development of hydrocephalus with prospective to be the auxiliary therapeutic method of hydrocephalus. © 2012 Xu et al.; licensee BioMed Central Ltd.




Xu, H., Tan, G., Zhang, S., Zhu, H., Liu, F., Huang, C., … Wang, Z. (2012). Minocycline reduces reactive gliosis in the rat model of hydrocephalus. BMC Neuroscience, 13(1). https://doi.org/10.1186/1471-2202-13-148

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