An efficient and catalyst-free synthesis of N-Arylidene-2-Arylimidazo[1,2-A]pyridine-3-ylamine derivatives via Strecker reaction under controlled microwave heating

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Abstract

An efficient one-pot multicomponent reaction of 2-Aminopyridine with aromatic aldehydes and either benzoyl cyanide or cyanamide in pyridine under controlled microwave heating afforded N-Aryldene-2-Arylimidazo[1,2-A]-pyridine-3-ylamine derivatives. The reaction is catalyst free and is of high atom economy.

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Abdel Hameed, A. M., Moustafa, M. S., Al-Mousawi, S. M., Awed, R. R., & Sadek, K. U. (2017). An efficient and catalyst-free synthesis of N-Arylidene-2-Arylimidazo[1,2-A]pyridine-3-ylamine derivatives via Strecker reaction under controlled microwave heating. Green Processing and Synthesis, 6(4), 371–375. https://doi.org/10.1515/gps-2017-0019

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