Erk1/2 inhibit synaptic vesicle exocytosis through L-type calcium channels

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Abstract

L-type calcium channels play only a minor role in basal neurotransmitter release in brain neurons but contribute significantly after induction of plasticity. Very little is known about mechanisms that enable L-type calcium channel participation in neurotransmitter release. Here, using mouse primary cortical neurons, we found that inhibition of Erk1/2 (extracellular signal-regulated kinases 1 and 2) enhanced synaptic vesicle exocytosis by increasing calcium influx through L-type calcium channels. Furthermore, inhibition of Erk1/2 increased the surface fraction of these channels. These findings indicate a novel inhibitory effect of Erk1/2 on synaptic transmission through L-type calcium channels. Copyright © 2011 the authors.

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Subramanian, J., & Morozov, A. (2011). Erk1/2 inhibit synaptic vesicle exocytosis through L-type calcium channels. Journal of Neuroscience, 31(12), 4755–4764. https://doi.org/10.1523/JNEUROSCI.6594-10.2011

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