Alcohol accumulation promotes esophagitis via pyroptosis activation

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Abstract

Gastroesophageal reflux impairs the mucosal barrier in the distal esophagus, allowing chronic exposure of the squamous epithelium to multitudinous stimulations and inducing chronic inflammation. Esophagitis is a response to inflammation of the esophageal squamous mucosa. Our study clarified that alcohol accumulation could aggravate the progress of esophagitis by inducing pyroptosis; however, Ac-YVAD-CMK, an inhibitor of caspase-1, could effectively suppress the expression of IL-1β and IL-18 both in vivo and in vitro, reducing the inflammatory response, which is promised to be an agent to inhibit the progression of esophagitis. Additionally, caspase-1-derived pyroptosis is involved in esophageal cancer.

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Wang, F., Li, G., Ning, J., Chen, L., Xu, H., Kong, X., … Ma, J. (2018). Alcohol accumulation promotes esophagitis via pyroptosis activation. International Journal of Biological Sciences, 14(10), 1245–1255. https://doi.org/10.7150/ijbs.24347

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