miR-221/222 are two highly homologous microRNAs that are frequently upregulated in solid tumors. However, the effects of miR-221/222 in malignant gliomas have not been investigated thoroughly. In this study, we found that miR-221/222 were significantly upregulated in human glioma samples and glioma cell lines. Both gain- and loss-of-function studies showed that miR-221/222 regulate cell proliferation, the cell cycle and apoptosis, in addition to, invasion, metastasis, and angiogenesis in glioma cell lines. Subsequent investigations revealed that TIMP2 is a direct target of miR-221/222, and overexpression of TIMP2 reduced the miR-221/222-mediated invasion, metastasis, and angiogenesis of glioma cells. Taken together, our results suggest that the suppression of miR-221/222 may be a feasible approach for inhibiting the malignant behaviors of glioma.
CITATION STYLE
Yang, F., Wang, W., Zhou, C., Xi, W., Yuan, L., Chen, X., … Wang, T. (2015). MiR-221/222 promote human glioma cell invasion and angiogenesis by targeting TIMP2. Tumor Biology, 36(5), 3763–3773. https://doi.org/10.1007/s13277-014-3017-3
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