Boron drug delivery via encapsulated magnetic nanocomposites: A new approach for BNCT in cancer treatment

Abstract

Ortho-carborane cages have been successfully attached to modified magnetic nanoparticles via catalytic azide-alkyne cycloadditions between 1-R-2-butyl-Ortho- C2 B10H10 (R = Me, 3; Ph, 4) and propargyl group-enriched magnetic nanoparticles. A loading amount of 9.83mmol boron atom/g starch-matrixed magnetic nanoparticles has been reached. The resulting nanocomposites have been found to be highly tumor-targeted vehicles under the influence of an external magnetic field (1.14T), yielding a high boron concentration of 51.4 μg/g tumor and ratios of around 10: 1 tumor to normal tissues. Copyright © 2010 Yinghuai Zhu et al.