Necrolytic migratory erythema in a dog

Abstract

We report here a case of Necrolytic Migratory Erythema (NME) seen in a dog with cirrhosis in which octreotide therapy succeeded. Histopathologic examination of skin revealed NME. Blood parameters and liver cytology result, USG and CT examination of liver and pancreas indicated a severe cirrhosis, however any mass or tumor couldn’t be found on pancreas at the time. In this case, the skin disease was believed to be due to a chronic hepatopathy (cirrhosis) associated with secondary hyperglucagonemia. Octreotide, high level of protein diet, fatty acids and zinc supplement were used, and this provided temporary relief of signs. Neurologic symptoms related to liver failure, profuse vomiting, weight loss and apparent pain were eventually observed and the patient was euthanized. Postmortem examination including gross necropsy and microscobic evaluation of skin, liver and pancreas tissues confirmed our diagnosis.