Integration of chrebp-mediated glucose sensing into whole body metabolism

Abstract

Since glucose is the principal energy source for most cells, many organisms have evolved numerous and sophisticated mechanisms to sense glucose and respond to it appropriately. In this context, cloning of the carbohydrate responsive element binding protein has unraveled a critical molecular link between glucose metabolism and transcriptional reprograming induced by glucose. In this review, we detail major findings that have advanced our knowledge of glucose sensing