Laccase-catalyzed 1,4-dioxane-mediated synthesis of belladine n-oxides with anti-influenza a virus activity

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Abstract

Belladine N-oxides active against influenza A virus have been synthetized by a novel laccase-catalyzed 1,4-dioxane-mediated oxidation of aromatic and side-chain modified belladine derivatives. Electron paramagnetic resonance (EPR) analysis confirmed the role of 1,4-dioxane as a co-oxidant. The reaction was chemo-selective, showing a high functional-group compatibility. The novel belladine N-oxides were active against influenza A virus, involving the early stage of the virus replication life cycle.

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Zippilli, C., Botta, L., Bizzarri, B. M., Nencioni, L., De Angelis, M., Protto, V., … Saladino, R. (2021). Laccase-catalyzed 1,4-dioxane-mediated synthesis of belladine n-oxides with anti-influenza a virus activity. International Journal of Molecular Sciences, 22(3), 1–14. https://doi.org/10.3390/ijms22031337

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