Reverse Tigroid Pattern in Pachygyria: A Novel Finding

Abstract

Pachygyria is considered a subtype of lissencephaly which, in turn, is a spectrum of disorders caused by abnormal neuronal migration. Clinical presentation in this disorder may be varied including microcephaly, developmental delay, facial dysmorphism, seizures, and mental retardation. Magnetic resonance imaging (MRI) of brain identifies the exact nature and extent of the disease and helps in delineating further plan of management. A Tigroid pattern on axial MRI scan and leopard pattern on a sagittal plane has been classically reported in disorders of myelin formation such as metachromatic leukodystrophy and Pelizaeus-Merzbacher disease. We present here a case of pachygyria who presented to us with some atypical features including tigroid-like stripes and leopard-like pattern on MRI brain which has not been reported in the medical literature previously.