The novel three-way variant t(6;17;15)(p21;q21;q22in acute promyelocytic leukemia with an FLT3-ITD mutation: A case report

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Abstract

Acute promyelocytic leukemia (APL) is characterized by the reciprocal translocation t(15;17)(q22;q21), resulting in the fusion of the promyelocytic leukemia gene at 15q22 with the retinoic acid receptor α at 17q21. Additionally, all patients with APL who have additional chromosome abnormalities (ACA) and gene mutations are resistant to all-trans retinoic acid (ATRA), the drug that causes disease regression specifically in patients with APL globally. The present study describes a case of a 19-year-old female with APL carrying a novel complex variant translocation t(6;17;15)(p21;q21;q22), add(7)(q32) and an FMS-related tyrosine kinase 3 internal tandem duplication (FLT3-ITD) mutation. Complete remission was attained following a course of chemotherapy with ATRA and arsenic trioxide. To the best of our knowledge, this is the first report of a novel three-way translocation of 6p21 and a FLT3-ITD mutation involved with APL.

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Zhang, Y. L., Jiang, M., Luan, S. Q., Liu, S. Y., Wan, J. H., Wan, L. G., & Zhang, Z. L. (2018). The novel three-way variant t(6;17;15)(p21;q21;q22in acute promyelocytic leukemia with an FLT3-ITD mutation: A case report. Oncology Letters, 16(5), 6121–6125. https://doi.org/10.3892/ol.2018.9413

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