Eight-day Inpatient Directly Observed Therapy for Antiretroviral Therapy (ART) Failure: A Tool for Preventing Unnecessary ART Changes and Optimizing Adherence Support

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Abstract

Eight-day inpatient directly observed therapy confirmed nonadherence as the major cause of virologic failure for 9 (45%) of 20 highly treatment-experienced persons with human immunodeficiency virus, extensive antiretroviral drug resistance, and high self-reported adherence rates, preventing unnecessary regimen changes.

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Winchester, N. E., Maldarelli, F., Mejia, Y., Dee, N., Dewar, R., Laidlaw, E., … Pau, A. K. (2020). Eight-day Inpatient Directly Observed Therapy for Antiretroviral Therapy (ART) Failure: A Tool for Preventing Unnecessary ART Changes and Optimizing Adherence Support. In Clinical Infectious Diseases (Vol. 70, pp. 1222–1225). Oxford University Press. https://doi.org/10.1093/cid/ciz590

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