Características clínico bioquímicas de pacientes con patología hipofisaria

Abstract

Objective: Descriptive studies in our country of hypophisis diseases are uncommon. Pituitary adenoma are unfrequent, however this pathology represent 10-12% of brain tumors. Pituitary adenomas are derived of adenohypophisis cells, depending of cellular line, clinical and biochemical characteristics are diferents. The aim of our study was to describe these characteristics in our patients. Material and methods: We study 58 patients with diagnosis of pituitary tumor, with regular follow-up in our Hospital, between 1999-2001. The next data were recorded: epidemiological, clinical and biochemical datas. Results: Average age at diagnosis was 36.4 years (DS 16.34 years), with a 70.61% of females. The most frequent tumor was prolactinoma and non-functioning adenomas, amenorrhea was the most frequent symptom with the specialist physician (15%) and the general practice physician was the first step in diagnosis protocol. Cerebral image technique was realized in 54 patients, with a 15.5% of normal exploration and 78.6% with lesions, with 24.14% of microadenoma and macroadenoma. Invasive lesions (craneopharingioms, germinomes and invasive adenomas) representing a 6.9%. Depression, hipertension and diabetes mellitus were the most frequent diseases in these patients. Conclusions: Prolactinoma is the most frequent hypophisis patology. Amenorrhea and/or galactorrhea are the most common symptom. Response to medical and surgical treatment was excelent in prolactinomas. Copyright © 2005 Aran Ediciones, S.L.