Flow chemistry has attracted significant interest in pharmaceutical development, where substantial efforts have been directed toward the design of continuous processes. Here, we report a total synthesis of atropine in flow that features an unusual hydroxymethylation and separation of several byproducts with high structural similarity to atropine. Using a combination of careful pH control in three sequential liquid-liquid extractions and a functionalized resin, atropine is delivered by the flow system with >98% purity.
CITATION STYLE
Dai, C., Snead, D. R., Zhang, P., & Jamison, T. F. (2015). Continuous-flow synthesis and purification of atropine with sequential in-line separations of structurally similar impurities. Journal of Flow Chemistry, 5(3), 133–138. https://doi.org/10.1556/1846.2015.00013
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