Persistent organochlorine pesticides in human milk samples from Australia

Abstract

Human milk has been used as a surrogate for the assessment of body burden and exposure to persistent lipophilic organochlorine pesticides (OCPs). With the exception of restricted use of mirex, the use of persistent, lipophilic OCPs has been banned in Australia since the 1980s. The decline of human body burden of OCPs following their ban in many industrialised countries is well recorded worldwide from the 1970s until the 1990s though little is known on whether these trends are continuing. In this study, 157 human milk samples collected during 2002 and 2003 as well as 24 samples collected in 1993 were analysed as 20 regional pools for 17 OCPs. OCPs were detected in all pooled human milk samples from 2002/03 typically with highest concentrations of p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE) (mean ± standard deviation; median concentration 311 ± 174; 279 ng g-1 lipid) followed by β-hexachlorocyclohexane (β-HCH) (80 ± 173; 21 ng g-1 lipid). Other OCPs consistently detected included dieldrin (16 ± 6; 17 ng g-1 lipid), hexachlorobenzene (HCB) (18 ± 16; 14 ng g-1 lipid), transnonachlor (11 ± 5; 9 ng g-1 lipid) and p,p′-dichlorodiphenyltrichloroethane (p,p′-DDT) (9 ± 6; 7 ng g-1 lipid). The results from this study indicated that following a substantial decline of OCP concentrations from the early 1980s to the 1990s, little decline could be observed since then. Furthermore the use of multivariate statistics indicated some regional trends with slightly higher levels of the broadly used insecticides DDT and HCH in both historic and recent samples from Melbourne, whereas, sample pools collected from mothers that lived in rural Queensland and New South Wales as well as Adelaide and Sydney showed comparatively higher levels of heptachlor and dieldrin - both of which have been used for termite treatment. These results indicate that even 20 years after the discontinuation of usage, historical use of OCPs rather than exposure via global transport of OCPs is responsible for continuous low exposure in Australia. © 2007 Elsevier Ltd. All rights reserved.