The main goal of cancer immunotherapy is to induce or boost tumor-specific effector cells able to eliminate or reduce tumor progression. In this study, we characterized lymphocyte phenotypes in melanoma patients receiving dendritic cell (DC)-based vaccinotherapy. We found that several biological markers served as unfavorable prognostic factors for patients' response to therapy. This included decrease of CD4+ and CD8+ lymphocyte levels, 10% and higher increase of CD16+CD3+CD8+ lymphocyte population, and increase of CD16+CD8+perforin +T lymphocytes, especially in combination with decreased levels of CD16+CD8-perforin+ and CD8+CD16 -perforin+ cells. Increase in CD8+CD16 -perforin+ T lymphocytes with normal levels of CD16 +CD8-perforin+ cells and the absence of CD16+CD8+perforin+ and regulatory lymphocytes were shown to be the positive prognostic markers for patients' response to DC vaccines. © 2007 Springer Science+Business Media, LLC.
CITATION STYLE
Kadagidze, Z. G., Borunova, A. A., & Zabotina, T. N. (2007). Lymphocyte subpopulations in melanoma patients treated with dendritic cell vaccines. In Advances in Experimental Medicine and Biology (Vol. 601, pp. 381–386). https://doi.org/10.1007/978-0-387-72005-0_41
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