Rivaroxaban has the most available data to support the use of prothrombin complex concentrates (PCC) as a reversal agent. However, PCC might increase the incidence of thrombotic events by shifting the haemostatic balance towards hypercoagulability. We assessed the in vitro efficacy and safety of three 4-factor PCCs for reversing rivaroxaban anticoagulant effect. Our in vitro finding indicates that 4-factor PCCs at the dose of 25 U.kg- 1 may be sufficient to reverse rivaroxaban anticoagulant effect.
CITATION STYLE
Giffard-Quillon, L., Desmurs-Clavel, H., Grange, C., Jourdy, Y., & Dargaud, Y. (2020). Reversal of rivaroxaban anticoagulant effect by prothrombin complex concentrates: Which dose is sufficient to restore normal thrombin generation? Thrombosis Journal, 18(1). https://doi.org/10.1186/s12959-020-00228-9
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