Future directions of infectious disease research

Abstract

Sequencing of bacterial genomes and comparative genomics provide novel approaches for the identification of previously unrecognized microbial pathogens that likely cause a variety of infectious diseases in humans and animals. In addition, the genetic approaches probably will discover new virulence determinants that can be used as targets in the development of novel intervention strategies for both the prevention and treatment of infectious diseases. This chapter cites specific examples in support of these contentions, with particular reference to recent advances of selected infectious and chronic inflammatory diseases involving the gastrointestinal tract. © 2006 Humana Press Inc.