Differential expression of HLA-DR, DQ, and DP antigens in primary and metastatic melanoma

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Abstract

Fifty-five primary and 33 metastatic surgically removed melanoma lesions were stained in indirect immunoperoxidase with anti HLA-DR, DQ, and DP monoclonal antibodies and with the monoclonal antibody CL203.4 to a 96-K melanoma associated antigen (MAA). The latter antigen may represent a marker to monitor susceptibility of melanoma cells to modulation by IFN-γ, because it is highly susceptible to induction by IFN-γ-. In primary melanomas 44%, 29%, 10%, and 55% of the lesions tested were evidently stained by anti HLA-DR, DQ, DP, and 96-K MAA monoclonal antibodies, respectively. A statistically significant association (P < 0.01) was demonstrated between the degree of intratumoral lymphocytic infiltrate and the expression of HLA-DR and HLA-DQ antigens. In addition, a high degree of concordance in the reactivity pattern of individual lesions stained for HLA-DR antigens and for the 96-K MAA was found. In metastases 64%, 33%, 47%, and 100% of the lesions tested were evidently stained by anti HLA-DR, DQ, DP, and 96-K MAA monoclonal antibodies, respectively. This study indicates that HLA-DR and HLA-DP antigens are expressed in a higher percentage of metastatic than of primary melanomas and that there is no marked difference in the expression of HLA-DQ antigens between primary and metastatic melanomas. The data suggest that the regulatory mechanisms which control the expression of HLA-DR and DP antigens in primary and metastatic melanoma lesions are different. Locally produced IFN-γ may play a role in the regulation of HLA Class II antigens in primary melanomas. © 1988.

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APA

van Vreeswijk, H., Ruiter, D. J., Bröcker, E. B., Welvaart, K., & Ferrone, S. (1988). Differential expression of HLA-DR, DQ, and DP antigens in primary and metastatic melanoma. Journal of Investigative Dermatology, 90(5), 755–760. https://doi.org/10.1111/1523-1747.ep12560951

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