Outcomes of Allogeneic stem cell transplantation among patients with acute myeloid leukemia presenting active disease: Experience of a single european comprehensive cancer center

2Citations
Citations of this article
29Readers
Mendeley users who have this article in their library.

Abstract

Introduction: Allogeneic hematopoietic stem cell transplantation (ASCT) represents a potentially curative approach for patients with relapsed or refractory acute myeloid leukemia (AML). We report the outcome of relapsed/refractory AML patients treated with ASCT. Method: A retrospective cohort from 1994 to 2013 that included 61 patients with diagnosis of relapsed/refractory AML. Outcomes of interest were transplant-related mortality (TRM), incidence of acute and chronic graft-versus-host disease (GVHD), relapse incidence, progression-free survival (PFS) and overall survival (OS). Statistical significance was set at p<0.05. Results: The median age was 61 years (range 1 to 65). The cumulative incidence of 90 days, 1 year, and 3 years TRM were 60%, 26.7%, and 13.3%, respectively (p<0.001). The incidence of relapse was 21.7% at 1 year, 13% at 3 years, and 8.7% at 5 years. Median OS was estimated to be 8 months (95CI 3.266-12.734) and median PFS, 3 months (95CI 1.835-4.165). Conclusion: In our cohort, TRM in first years after ASCT remains considerable, but ASCT in this setting seems to be a good choice for AML patients with active disease. However, novel approaches are needed to reduce TRM and relapse in this set of patients.

Cite

CITATION STYLE

APA

De-Mello, R. A. B., Pinho-Vaz, C., Branca, R., Campilho, F., Rosales, M., Roncon, S., & Campos-Júnior, A. (2016). Outcomes of Allogeneic stem cell transplantation among patients with acute myeloid leukemia presenting active disease: Experience of a single european comprehensive cancer center. Revista Da Associacao Medica Brasileira, 62(7), 641–646. https://doi.org/10.1590/1806-9282.62.07.641

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free