Association of IL-10 and IL-6 gene polymorphisms with type 2 diabetes mellitus among Egyptian patients

Abstract

Recent findings indicate that certain cytokines are capable of interfering with insulin sensitive glucose uptake and induce insulin resistance. To test for the association of IL-10-1082 and IL-6-174 genetic polymorphisms with type 2 diabetes mellitus in Egyptian patients. Participants included 69 cases with type 2 DM (31 males and 38 females) with a median age of 57 years in addition to 98 healthy unrelated controls from the Nile Delta region, Egypt. Compared to controls, cases with type 2 diabetes mellitus showed a highly significant increase in the frequency of IL-10-1082 GG genotype (p<0.001, OR = 11.24); higher frequency of IL-10-1082 G allele (p<0.001, OR = 2.2) with a significantly lower frequency of IL-10-1082 GA genotype (p<0.001, OR = 0.22). On the other hand, the IL-6-174 CC genotype frequency was significantly higher in the diabetic group (p<0.001, OR = 5.41) in contrast to the IL-6-174 GC genotype that showed significantly lower frequency (p=0.005, OR = 0.31) with a non significant differences in either G or C allelic frequencies between diabetic and control groups (p>0.05). Polymorphisms related to IL-10-1082 GG and IL-6-174 CC genotypes may be considered as a risk factor for type 2 diabetes mellitus among Egyptian subjects with a potential impact on family counseling and management.