Imaging approach to hemoglobinopathies

Abstract

Hematologic disorders of the skeleton produce radiologic appearances related to marrow infiltration and/or replacement. These include common findings, such as osteopenia with trabecular prominence, growth disturbances, and extramedullary hematopoiesis. Most entities also manifest with various typical imaging features and appear in characteristic distributions, which aids in their differentiation and clinical management. In this chapter, we will discuss imaging appearances of sickle cell disease, thalassemia, and other rare causes of anemia. © 2010 Humana Press.