The growth arrest and DNA damage-inducible (Gadd)45 proteins have been associated with numerous cellular mechanisms including cell-cycle control, DNA damage sensation and repair, genotoxic stress, neoplasia, and molecular epigenetics. The genes were originally identified in in vitro screens of irradiation-and interleukin-induced transcription and have since been implicated in a host of normal and aberrant central nervous system processes. These include early and postnatal development, injury, cancer, memory, aging, and neurodegenerative and psychiatric disease states. The proteins act through a variety of molecular signaling cascades including the MAPK cascade, cell-cycle control mechanisms, histone regulation, and epigenetic DNA demethylation. In this review, we provide a comprehensive discussion of the literature implicating each of the three members of the Gadd45 family in these processes. © Springer Science+Business Media New York 2013.
CITATION STYLE
Sultan, F. A., & Sweatt, J. D. (2013). The role of the Gadd45 family in the nervous system: A focus on neurodevelopment, neuronal injury, and cognitive neuroepigenetics. Advances in Experimental Medicine and Biology, 793, 81–119. https://doi.org/10.1007/978-1-4614-8289-5_6
Mendeley helps you to discover research relevant for your work.