Abstract
The natural mutant mouse rolling Nagoya is severely ataxic and frequently shows body roll-overs. A missense mutation was identifi ed in Cacna1a, the gene encoding the a 1 pore subunit of Ca V 2.1 type voltage-gated Ca 2+ channels. We here discuss the main phenotypic and neuronal characteristics of this mutant, with relevance to the human neurological disorders associated with Ca V 2.1 dysfunction (‘Ca 2+ -channelopathies’).
Author supplied keywords
Cite
CITATION STYLE
Plomp, J. J., van den Maagdenberg, A. M. J. M., & Tolner, E. A. (2016). The rolling Nagoya mouse. In Essentials of Cerebellum and Cerebellar Disorders: A Primer for Graduate Students (pp. 443–448). Springer International Publishing. https://doi.org/10.1007/978-3-319-24551-5_60
Register to see more suggestions
Mendeley helps you to discover research relevant for your work.
