Aculeximycin, a new antibiotic from streptosporangium albidum i. taxonomy of producing organism and fermentation

Abstract

A soil isolate of actinomycete, strain Tl-l, was found to produce a new antibiotic aculeximycin which killed insects as well as inhibited the growth of bacteria, yeasts and molds in vitro. Yellowish gray colonies on agar media, formation of spherical to oval sporangia at the tip of aerial mycelium and the presence of meso-diaminopimelic acid and madurose in the cell wall ascribed this strain to genus Streptosporangium. From its morphological, cultural and physiological characteristics, the strain was determined to be S. albidum. Production of aculeximycin was carried out by conventional submerged culture: the highest antibiotic titer obtained was 1,250 μg/ml. © 1983, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.