Aqueous Suspensions

Abstract

A good formulation of coarse particles dispersed in a liquid vehicle is facilitated by an understanding of the theory of particle technology and methodologies to assess physical properties of the resulting product. Formulation parameters include particle–vehicle interactions, sedimentation/flocculation kinetics, particle size and crystal form identity and stability, and appropriate suspension rheology to aid flocculation and minimize caking. The vehicle and stabilizers added must allow for creation of a flocculated system, prevent caking, and promote rapid redispersion. Additional delivery considerations include irritation and pain potential, in vitro vs. in vivo release methodologies, and the targeted delivery profile.