Prevalence of Extended-Spectrum Beta Lactamase-Producing Microorganisms in Dr. Mohammad Hoesin Hospital Palembang

Abstract

Production of Extended-Spectrum Beta-Lactamase (ESBL) by Enterobacteriaceae remains a problem for infectious diseases, especially in hospitals. The main causes of ESBL-producing bacteria colonization are urinary tract infections, length of hospital stay, invasive medical equipment, and antibiotics usage. This study aimed to compare the incidence of ESBL based on the type of organism in Dr. Mohammad Hoesin Hospital in 2017 and 2018. The research design used was descriptive with a cross-sectional approach, which used secondary data at the Department of Clinical Pathology of Dr. Mohammad Hoesin Hospital, Palembang. The findings of this study showed a decreasing pattern in the incidence of ESBL in 2017 and 2018, but with a similar pattern, which was dominated by Klebsiella pneumoniae (followed by Escherichia coli and Klebsiella ozaenae) among inpatients in pediatric wards, internal medicine, and intensive care units, and on sputum specimens. This study showed the high prevalence of ESBL-producing bacteria (>60%) in Dr. Mohammad Hoesin Hospital, which was mainly caused by Klebsiella pneumoniae.