Comparing executive functions in children with attention deficit hyperactivity disorder with or without reading disability: A resting-state EEG study

Abstract

Introduction: As numerous studies have shown, executive dysfunction is the main impairment in attention-deficit/hyperactivity disorder. According to recent neuroimaging studies, the frontoparietal coherence plays a key role in overall cognitive functions. Therefore, the aim of this study was to compare executive functions during resting-state EEG by monitoring brain connectivity (coherence) patterns in children with attention deficit hyperactivity disorder (ADHD) with or without reading disability (RD). Methods: The statistical sample of the study consisted of 32 children with ADHD aged between 8 and 12 years old with or without specific RD. Each group consisted of 11 boys and 5 girls that were matched on chronological age and gender. EEG was recorded during eyes-opened condition and brain connectivity within and between frontal and parietal regions was analyzed within theta, alpha, and beta bands. Results: The results revealed that across the frontal regions, the comorbid group showed a significant reduction in the left intrahemispheric coherence in the alpha and beta bands. The ADHD-alone group exhibited increased theta and decreased alpha and beta coherence in frontal regions. In the frontoparietal regions, children in the comorbid group showed lower coherence between frontal and parietal networks compared to children without comorbid RD. Conclusion: The findings indicate that brain connectivity (coherence) patterns of children with ADHD with comorbid RD were more abnormal and lend support to more disrupted cortical connectivity in the comorbid group. Thus, these findings can be a useful marker for better recognizing ADHD and comorbid disabilities.