Synthesis and anticonvulsant properties of 1,2,3,4-tetrahydroisoquinolin-1-ones

Abstract

Following our previous molecular modeling studies we herein report the synthesis of substituted 1,2,3,4-tetrahydroisoquinolinone-4-carboxylic acids in an attempt to obtain new anticonvulsants acting as negative modulators of AMPA-type glutamate receptor. The evaluation of their pharmacological effects demonstrated that some derivatives were able to prevent audiogenic induced seizures in DBA/2 mice.