Artificial oligoamino acids with appropriate protecting groups can be used for the sequential assembly of oligoaminoamides on solid-phase. With the help of these oligoamino acids multifunctional nucleic acid (NA) carriers can be designed and produced in highly defined topologies. Here we describe the synthesis of the artificial oligoamino acid Fmoc-Stp(Boc3)-OH, the subsequent assembly into sequence-defined oligomers and the formulation of tumor-targeted plasmid DNA (pDNA) polyplexes.
CITATION STYLE
Morys, S., Wagner, E., & Lächelt, U. (2016). From artificial amino acids to sequence-defined targeted oligoaminoamides. In Methods in Molecular Biology (Vol. 1445, pp. 235–258). Humana Press Inc. https://doi.org/10.1007/978-1-4939-3718-9_15
Mendeley helps you to discover research relevant for your work.