Development of nitric-oxide-sensor-based gold (Au) and platinum (Pt) metals on screen-printed electrode modified graphene

Abstract

Nitric oxide (NO) plays an important role in physiological processes. NO measurement accuracy is important to understand the essential functions of NO but attaining these levels of accuracy is difficult due to NO's short half-life. NO concentrations can be determined using an analytical method that has fast response and high sensitivity and is simple and practical. In this study, gold and platinum metals are deposited onto a screen-printed electrode (SPE) surface in a solution mixture of HAuCl4 in 0.05 M H2SO4 and K2PtCl6, in 0.05 M H2SO4, which has been modified with graphene to detect NO. Experiments that varied the deposition concentrations of the Au/Pt onto the G/SPE are conducted to obtain an optimal deposit concentration ratio between AuPt and G/SPE. NO detection tests are conducted at +0.878 V against Ag/AgCl. Deposits of AuPt/G/SPE that have 1:1 concentrations form high-performance sensors due to its high sensitivity at 23029.92 μA mM-1 cm-2, a low detection limit of 2.2 - 10-3 mM, and the best linearity, R2 = 0.9943. No is detected using the Griess Saltzman method. Based on the linearity results from the NO detection measurements, we observe that the electrochemical method provides significant improvements over the Griess Saltzman method.