Effect of protein intake on tumor growth and cell cycle kinetics

1Citations
Citations of this article
6Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Previous research has documented significant acceleration of tumor growth in animals receiving short-term parenteral nutrition. This study was performed to determine the effect of long-term enteral protein intake on tumor cell cycle kinetics in the tumor-bearing host. Fifty Lewis/Wistar rats with subcutaneous mammary tumor implants (AC-33) were randomized to receive a standard protein diet (22.0% protein; 4.20 kcal/g) or protein-depleted diet (0.03% protein; 4.27 kcal/g). Animals were sacrificed after 7 or 14 days on each diet and tumor cytokinetics determined by flow cytometry. Tumor volume was significantly reduced in animals receiving the protein-depleted versus standard protein diet after 14 days (P < 0.01). No difference was found in tumor cell cycle kinetics (% G0/G1, S, or G2/M populations) or tumor growth fraction (S + G2/M) in animals receiving standard or protein-depleted diet after 7 or 14 days. These results suggest that reduced tumor growth with prolonged protein depletion in this model occurs by either (a) movement of tumor cells from the active cell cycle to the dormant Go state or (b) uniform increase of cell cycle duration without changing the relative proportion of cells throughout the cell cycle. The potential therapeutic implications of nutrient-induced alterations in tumor growth are discussed. © 1995 Academic Press, Inc.

Cite

CITATION STYLE

APA

Torosian, M. H. (1995). Effect of protein intake on tumor growth and cell cycle kinetics. Journal of Surgical Research, 59(2), 225–228. https://doi.org/10.1006/jsre.1995.1158

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free