Secondary metabolites from the liverwort Ptilidium pulcherrimum

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Abstract

A new trinortriterpenoid, diospyrolide acetate (1) and a new diphenylmethane derivative, pulcherrimumin (12), together with ten known pentacyclic triterpenoids (2-11) and four aromatic compounds (13-16), were isolated from the liverwort Ptilidium pulcherrimum. Their structures were established on the basis of extensive analysis of NMR data and by chemical methods. The cytotoxicity of compounds 1-16 was evaluated against the PC3, MDA-MB-231, and Hela cells lines. Ursane triterpenoids 8-10 exhibited moderate cytotoxicity against PC3 cells with IC50 values ranging from 10.1 to 39.7 μM.

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Guo, D. X., Du, Y., Wang, Y. Y., Sun, L. M., Qu, J. B., Wang, X. N., & Lou, H. X. (2009). Secondary metabolites from the liverwort Ptilidium pulcherrimum. Natural Product Communications, 4(10), 1319–1322. https://doi.org/10.1177/1934578x0900401001

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