Drug-induced liver disease during continuous epidural block with bupivacaine

Abstract

BUPIVACAINE is a widely used and generally safe local anesthetic. Although adverse reactions to bupivacaine have been reported, most of them are caused by accidental intravascular injection or overdosage. Other cases include anaphylactoid reactions and delayed cutaneous reactions. We present four cases of liver injury that occurred during management of postherpetic neuralgia (PHN) and lumbar disc hernia by continuous epidural block with bupivacaine.