Design, synthesis and antimycobacterial evaluation of some new azaheterocycles with the 4,7-phenanthroline skeleton. Part VI

Abstract

A feasibility study concerning the synthesis, structure and in vitro antimycobacterial evaluation of new 4,7-phenanthroline derivatives is reported. The preparation is straightforward and efficient, involving an N-alkylation reaction of 4,7-phenanthroline. The structure of the new compounds were verified by elemental and spectral (IR, 1H-and 13C-NMR) analysis. The in vitro antimycobacterial evaluation of the five synthesized compounds was investigated against Mycobacterium tuberculosis H37Rv under aerobic conditions. A certain influence of substituents on the para position of the benzoyl moiety was observed; the 4,7-phenanthrolin-4-ium salt substituted with p-chlorobenzoyl group showing the most pronounced antimycobacterial activity.