Telomere dynamics in rhesus monkeys: No apparent effect of caloric restriction

35Citations
Citations of this article
55Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

The role of telomere attrition in limiting the replicative capacity of cells in culture is well established. In humans, epidemiologic evidence suggests telomere length (TL) in leukocytes is highly variable at birth and inversely related to age. Although calorie restriction (CR) significantly increases life span in most rodent models, its association with TL is unknown. Using linear regression analysis, TLs (as measured by Southern blot analysis) of skeletal muscle (a postmitotic tissue that largely represents early development TL), fat, leukocytes, and skin were tested for effects of age, sex, and diet in 48 control and 23 calorie restriction rhesus monkeys. After controlling for the individual's muscle mean TL, differences between leukocytes muscle and skin muscle were significantly associated with age (p =. 002; p =. 002) and sex (p =. 003; p =. 042), but not calorie restriction (p =. 884; p =. 766). Despite an age-dependent shortening of TL in leukocytes and skin, calorie restriction did not significantly affect TL dynamics in these samples. © 2011 The Author.

Cite

CITATION STYLE

APA

Smith, D. L., Mattison, J. A., Desmond, R. A., Gardner, J. P., Kimura, M., Roth, G. S., … Aviv, A. (2011). Telomere dynamics in rhesus monkeys: No apparent effect of caloric restriction. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 66 A(11), 1163–1168. https://doi.org/10.1093/gerona/glr136

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free