Smoking-related idiopathic interstitial pneumonia

31Citations
Citations of this article
66Readers
Mendeley users who have this article in their library.

Abstract

Cigarette smoking is a key factor in the development of numerous pulmonary diseases. An international group of clinicians, radiologists and pathologists evaluated patients with previously identified idiopathic interstitial pneumonia (IIP) to determine unique features of cigarette smoking. Phase 1 (derivation group) identified smoking-related features in patients with a history of smoking (n541). Phase 2 (validation group) determined if these features correctly predicted the smoking status of IIP patients (n5100) to participants blinded to smoking history. Finally, the investigators sought to determine if a new smoking-related interstitial lung disease phenotype could be defined. Phase 1 suggested that preserved forced vital capacity with disproportionately reduced diffusing capacity of the lung for carbon monoxide, and various radiographic and histopathological findings were smoking-related features. In phase 2, the kappa coefficient among clinicians was 0.16 (95% CI 0.11-0.21), among the pathologists 0.36 (95% CI 0.32-0.40) and among the radiologists 0.43 (95% CI 0.35-0.52) for smoking-related features. Eight of the 100 cases were felt to represent a potential smoking-related interstitial lung disease. Smoking-related features of interstitial lung disease were identified in a minority of smokers and were not specific for smoking. This study is limited by its retrospective design, the potential for recall bias in smoking history and lack of information on second-hand smoke exposure. Further research is needed to understand the relationship between smoking and interstitial lung disease. ©ERS 2014.

Cite

CITATION STYLE

APA

Flaherty, K. R., Fell, C., Aubry, M. C., Brown, K., Colby, T., Costabel, U., … Martinez, F. J. (2014). Smoking-related idiopathic interstitial pneumonia. European Respiratory Journal, 44(3), 594–602. https://doi.org/10.1183/09031936.00166813

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free