Diabetes and female sterility/infertility

Abstract

AGEs (advanced glycation end products) are pro-inflammatory molecules that trigger a state of intracellular oxidative stress and inflammation after binding to their cell membrane receptors, such as RAGE. The activation of the AGE-RAGE axis has been well known to play a role in type 2 diabetes mellitus (T2DM), obesity, metabolic syndrome (MetS), cardiovascular disease (CVD), aging, inflammation, and neurodegenerative disorders. AGEs might contribute to the etiology of polycystic ovary syndrome and infertility. This article explains for the relationship between the AGE-RAGE system and infertility as well as ovarian reserve in women of reproductive age.