Elevated proportion of small, dense low-density lipoprotein particles and lower adiponectin blood levels predict early structural valve degeneration of bioprostheses

13Citations
Citations of this article
19Readers
Mendeley users who have this article in their library.

Abstract

Objectives: Long-term durability of bioprosthetic heart valves (BPs) are limited by structural valve degeneration (SVD) leading to stenosis and/or regurgitation. In this study, we sought to determine the metabolic markers associated with SVD. Methods: In a cohort of 220 patients with an aortic BP (mean follow-up of 2.5 ± 1.2 years), we compared the metabolic and blood lipid profile including the levels of adiponectin and the proportion of small, dense low-density lipoprotein (LDL) particles (%LDL <255Å) in individuals developing echocardiographic evidence of early BP hemodynamic dysfunction with subjects having no features of BP dysfunction. Results: Patients developing BP dysfunction (n = 69; 31.3%) had a tendency of higher triglyceride levels. Moreover, patients with BP dysfunction had an increased proportion of %LDL <255Å. In multivariate linear regression analysis, after adjustment for age, gender, BP size and hypertension, the %LDL <255Å (p = 0.04) was significantly associated with BP dysfunction. In addition, patients with an elevated level of %LDL <255Å along with a decreased plasma adiponectin level were at a very high risk of developing early BP hemodynamic dysfunction (OR = 2.54, p = 0.04). Conclusion: BP dysfunction is significantly associated with an increased proportion of small, dense LDL. Copyright © 2012 S. Karger AG, Basel.

Cite

CITATION STYLE

APA

Shetty, R., Girerd, N., Côté, N., Arsenault, B., Després, J. P., Pibarot, P., & Mathieu, P. (2012). Elevated proportion of small, dense low-density lipoprotein particles and lower adiponectin blood levels predict early structural valve degeneration of bioprostheses. Cardiology, 121(1), 20–26. https://doi.org/10.1159/000336170

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free