Abstract
Secretory-pathway Ca2+-transport ATPases (SPCA) provide the Golgi apparatus with Ca2+ and Mn2+ needed for the normal functioning of this organelle. Loss of one functional copy of the human SPCA1 gene (ATP2C1) causes Hailey-Hailey disease, a rare skin disorder characterized by recurrent blisters and erosions in the flexural areas. Here, we will review the properties and functional role of the SPCAs. The relationship between Hailey-Hailey disease and its defective gene (ATP2C1) will be adressed as well
Author supplied keywords
Cite
CITATION STYLE
Vanoevelen, J., Dode, L., Raeymaekers, L., Wuytack, F., & Missiaen, L. (2007). Diseases involving the Golgi calcium pump. Subcellular Biochemistry, 45, 385–404. https://doi.org/10.1007/978-1-4020-6191-2_14
Register to see more suggestions
Mendeley helps you to discover research relevant for your work.
