A novel substrate directed multicomponent reaction for the syntheses of tetrahydro-spiro[pyrazolo[4,3-f]quinoline]-8,5'-pyrimidines and tetrahydro-pyrazolo[4,3-f]pyrimido[4,5-b]quinolinesviaselective multiple C-C bond formation under metal-free conditions

43Citations
Citations of this article
14Readers
Mendeley users who have this article in their library.

Abstract

A versatile and substrate oriented multicomponent reaction for the syntheses of novel highly diastereoselective tetrahydro-1'H-spiro[pyrazolo[4,3-f]quinoline-8,5'-pyrimidine]-2',4',6'(3'H)-triones (d.r. up to 20?:?1 (syn?:?anti)) and tetrahydro-8H-pyrazolo[4,3-f]pyrimido[4,5-b]quinoline-8,10(9H)-dionesviaformation of selective multiple C-C bonds under identical reaction conditions (viz.ethanol as a reaction medium and deep eutectic mixture as a catalyst) is demonstrated. Both approaches involve mild reaction conditions, use of non-hazardous solvents, and facilitate good to excellent reaction yields of the target compounds.

Cite

CITATION STYLE

APA

Patel, D. M., Patel, H. J., Padrón, J. M., & Patel, H. M. (2020). A novel substrate directed multicomponent reaction for the syntheses of tetrahydro-spiro[pyrazolo[4,3-f]quinoline]-8,5’-pyrimidines and tetrahydro-pyrazolo[4,3-f]pyrimido[4,5-b]quinolinesviaselective multiple C-C bond formation under metal-free conditions. RSC Advances, 10(33), 19600–19609. https://doi.org/10.1039/d0ra02990d

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free