LncRNA-MM2P downregulates the production of pro-inflammatory cytokines in acute gouty arthritis

Abstract

Acute gouty arthritis (AGA) is characterized by the accumulation of pro-inflammatory cytokines, which are immunological responses to monosodium urate (MSU) crystals. It has been demonstrated that long non-coding RNA (lncRNA)-MM2P is a novel regulator of M2 polarization of macrophages. The aim of the present study was to investigate whether lncRNA-MM2P regulates the MSU-induced inflammatory process. In cell models of RAW 264.7 and THP-1-derived macrophages, decreased expression of lncRNA-MM2P was observed in lipopolysaccharide- and MSU-treated macrophages, which was accompanied with obvious inflammatory responses. Using small interfering RNA to knockdown lncRNA-MM2P led to the upregulation of MSU-mediated inflammatory responses, both in RAW 264.7 and THP-1-derived macrophages. In conclusion, lncRNA-MM2P could be an important regulator of MSU-induced inflammation, and therefore could be involved in the development of AGA.