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An improved synthesis of 7, 8-epoxy-1,3,11-cembratriene15r(α), 16-diol, a cembranoid of marine origin with a potent cancer chemopreventive activity

Marine Drugs (2004) 2(1)
DOI: 10.3390/md201001
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Abstract

An effective method for the synthesis of 7,8-epoxy-1,3,11-cembratriene15R(α),16-diol and its in vitro Epstein-Barr Virus Early Antigen (EBV-EA) Activation Chemopreventive Assay are reported. This semisynthetic product is a new cembranoid with a potent tumor inhibitory activity that is expected to be a lead compound for a new class of chemopreventive agents of marine origin.

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Fahmy, H., Khalifa, S. I., Konoshima, T., & Zjawiony, J. K. (2004). An improved synthesis of 7, 8-epoxy-1,3,11-cembratriene15r(α), 16-diol, a cembranoid of marine origin with a potent cancer chemopreventive activity. Marine Drugs, 2(1). https://doi.org/10.3390/md201001

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